Do not take more or less of Glucophage than directed by your doctor. Glucophage should be taken with food to reduce the possibility of nausea or diarrhea, especially during the first few weeks of therapy.

If taking Glucophage XR, be sure to swallow the tablet whole; do not crush it or chew it. The inactive ingredients in the Glucophage tablet may occasionally appear in the stool. This is not a cause for concern. Your doctor will tailor your Glucophage dosage to your individual needs.

Glucophage dosage for adults:

• Glucophage: The usual starting of Glucophage dose is one 500-milligram tablet twice a day, taken with morning and evening meals. Your doctor may increase your daily Glucophage dose by 500 milligrams at weekly intervals, based on your response up to a total of 2,000 milligrams.
  
  An alternative starting Glucophage dose is one 850-milligram tablet a day, taken with the morning meal. Your doctor may increase this by 850 milligrams at 14-day intervals, to a maximum of 2,550 milligrams a day.
  
  The usual maintenance dose ranges from 1,500 to 2,550 milligrams daily. If you take more than 2,000 milligrams a day, your doctor may recommend that the medication be divided into three doses, taken with each meal.
  
  
• Glucophage XR: The usual starting dose of Glucophage is one 500-milligram tablet once daily with the evening meal. Your doctor may increase your dose by 500 milligrams at weekly intervals, up to a maximum dosage of 2,000 milligrams a day. If a single 2,000-milligram dose fails to control your blood sugar, you may be asked to take 1,000-milligram doses twice a day. If you need more than 2,000 milligrams a day, the doctor will switch you to regular Glucophage.

Glucophage dosage for older people:
Older people and those who are malnourished or in a weakened state are generally given lower doses of Glucophage because their kidneys may be weaker, making side effects more likely.

Glucophage for Children:

• Glucophage: For children 10 to 16 years old, the usual starting dose of Glucophage is one 500-milligram tablet twice a day with meals. The dosage may be increased by 500 milligrams at weekly intervals up to a maximum of 2,000 milligrams daily. Glucophage has not been tested in children younger than 10.
  
  
• Glucophage XR: This form of Glucophage has not been tested in children younger than 17.

Glucophage Overdose: An overdose of Glucophage can cause lactic acidosis. (See "What Side Effects May Occur?") If you suspect a Glucophage overdose, seek emergency treatment immediately.

If you miss a dose of Glucophage: Take the missed dose of Glucophage as soon as you remember. If it is almost time for your next Glucophage dose, skip the missed dose of Glucophage and go back to your regular schedule. Never take 2 Glucophage doses at the same time.

Storage instructions for Glucophage: Store Glucophage at room temperature.

Preparations of Glucophage:

• Glucophage Tablets: 500 mg, 850 mg, 1000 mg.
• Glucophage XR (extended release) Tablets: 500 mg, 750 mg

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